Katherine Heigl is to quit TV hit Grey's Anatomy after six seasons.
Makers ABC confirmed that Heigl's final appearance in the medical drama aired on January 21, four months before the show's season finale in May.
ABC Studios said Heigl was ending her run as Dr Izzie Stevens by "mutual agreement".
Heigl said that she asked to be let out of her contract 18 months early because of her new role as mother to an adopted daughter. The 31-year-old actress is married to singer-songwriter Josh Kelley.
Heigl launched a successful movie career during her tenure on Grey's Anatomy, including the box-office hit Knocked Up.