CityJet is to launch a new, 18-times weekly service between Cork and London City Airport from October.
The airline said it will fly three times daily on weekdays, with its first flight from Cork to London City Airport (LCY) departing at 07.40am.
It will also offer one flight on Saturdays and two on Sundays.
The airline, headquartered in Swords, says it saw significant potential in Cork and the greater Munster region for flights directly into London City.
Cork Airport Managing Director Niall MacCarthy welcomed the route.
“Over 800,000 passengers from the region already travel on our London services each year, making it the most popular destination from Cork Airport," he said.
Tickets for the new flights, which include complimentary on-board catering and a 23kg baggage allowance, are now on sale.
Cork Airport welcomes over 2.14 million passengers annually, although the number has dropped in recent years, despite a €120m investment in its new terminal.
Last month, CZA Czech Airlines opted to drop its proposed new flights from Cork to Prague and Ibiza, after advance bookings failed to meet expectations.
The CityJet service will add 3,420 seats a week.
"There are very good reasons to feel confident about the future of Cork Airport and it is now up to the people of the wider Cork region to ensure that their airport is supported," said Minister for Transport, Sport and Tourism, Paschal Donohoe.
London City Airport
“Our experience in operating into and out of London City Airport is that any passengers who try it remain on the route," said CityJet's executive chairman, Pat Byrne.
London City Airport offers relatively fast and easy access to the city - due to its small size and a location directly on the Docklands Light Railway network.
CityJet has seen significant growth in traffic in recent months as it has embarked on a major marketing drive both in Ireland and overseas.
Last month, the airline announced a 50pc increase in passenger numbers in May year on year on its Dublin to London City route.