DISABILITY agency Rehab plans to recruit 150 staff within a year.
Chief executive Angela Kerins said the move is part of a plan to create 400 jobs over the next three years.
The not-for-profit organisation has begun recruiting 73 of the workers to expand its services to people with disabilities.
The new posts are in training, education, health and social care, IT, sales and marketing, management and administration.
It is understood that some of the instructor roles include training in graphic design, horticulture, catering and providing people with disabilities with skills for the workplace.
Announcing the jobs, Minister for Jobs, Enterprise and Innovation, Richard Bruton, said Rehab had branched out to compete in export markets and created large scale employment.
Rehab Group employs over 2,500 staff in Ireland, and another 1,000 in the UK, Poland and the Netherlands. Ms Kerins, who earns €234,000 a year, said the group had developed a significant growth strategy up to 2015.
She said the group provides health, care, education and training to 56,000 people and aims to increase this to 75,000 by 2015.
Rehab also runs businesses and is Ireland's largest processor of glass for recycling, exporting nearly 100,000 tonnes per year. Details of the new jobs are available on www.rehab.ie.
The company, which receives state funding, was in the spotlight earlier this year after it announced plans to make 18 workers redundant, including workers with disabilities, at a Galway recycling plant.
Separately, the Labour Court ruled it should refund pay cuts imposed on staff, at a cost of over €2m.
The court found Rehab should repay part of the pay cuts that hit wages in 2010 because it failed to negotiate the cuts properly with staff.
Ms Kerins' salary is under scrutiny as part of a probe by the Department of Health into how charities spend €1.5bn in state funding.