Vandals have thrown buckets of paint over the remembrance wall erected in Glasnevin Cemetery last year to mark the centenary of the 1916 Rising.
The memorial wall is a tribute to Irish and British military and civilians who lost their lives during the 1916 Rising.
Paint was thrown on the wall, which is officially called the Necrology Wall, on Saturday night.
Gardai in Mountjoy are investigating the incident after being alerted early Sunday morning.
The Glasnevin Trust, which operates the historic graveyard, has issued a statement describing it as "an act of callous vandalism".
"Glasnevin Trust is currently engaging with the gardaí on the matter and will not be commenting further at this time," added the statement.
Without distinction between the two nationalities, the wall lists the names of everyone who died during the 1916 conflict, in chronological and alphabetical order.
It was unveiled last year during an interfaith ceremony led by President Higgins.
However, protests against the inclusion of deceased British military on the wall disrupted the beginning of the ceremony as people rallied outside the cemetery holding republican flags.
A youth (15) was arrested for a public order offence during the ceremony when he threw a firework at the wall.