Three pharmacists were struck off after fitness to practise inquiries last year, and seven others were sanctioned.
There were 50 formal complaints lodged relating to conduct, practice, behaviour and health of the pharmacists, said the Pharmaceutical Society of Ireland, which regulates the profession.
Another 133 concerns were received relating to behaviour, dispensing errors, failure to supply medicines and out-of-date drugs.
The majority of grievances came from the public, with nearly one in 10 from other pharmacists, the regulator's annual report revealed.
The report shows more pharmacies are opening. The number grew from 1,931 in 2017 to 1,945 last year.
There were 30 investigations open early last year and another seven during 2018.
Investigations are undertaken where there is a reason to believe serious safety issues or major non-compliance issues exist in relation to a pharmacist or pharmacy.
Some 41 actions were taken by the regulator in relation to the internet supply of non-prescription medicines.
Overall there were 149 pharmacy inspections conducted in 2018.
Females represent 58pc of new pharmacists who were registered. Registrar Niall Byrne said feedback from the public continues to reflect a high level of trust in pharmacists. More than two million customer visits are made every month.