Construction workers involved in building the new National Children's Hospital on the campus of St James's Hospital in Dublin will be banned from using its parking facilities.
The move is part of the bid to secure planning permission for the long-awaited €650m hospital with the aim of having it ready by mid-2019.
A planning application will be submitted with an Bord Pleanala at the end of next month, but an oral hearing is inevitable in the autumn to allow local residents and others to air their objections.
Project Director John Pollock said he is hopeful of securing permission in January for the seven-storey building and being able to turn the first sod in February.
He said the National Paediatric Hospital Board has been involved in "extensive engagement" with residents and patient groups. It unveiled the latest plan to Oireachtas members yesterday.
The planning application will also include the proposed satellite centres in Connolly Hospital and Tallaght Hospital, both of which should be open in two years.
In order to minimise disruption, construction workers will not be allowed to park in the grounds and special park and ride arrangements will be agreed to for those using the Luas.
There will also be less car parking spaces for hospital staff, who will also be encouraged to use public transport, walk or cycle where it is appropriate.
The design team is finalising the designs.
"We have got feedback from the residents on O'Reilly Avenue that we might damage their houses, so we have asked engineers to conduct surveys," Mr Pollock added.
The site is on 12 acres and has room for expansion to include a maternity hospital over time.
The €650m cost has been guaranteed by the Government.