Friday 24 May 2019

'Frankenstein' scientists bring pigs' brains back to life hours after death

Photo: PA
Photo: PA

John von Radowitz

A bizarre Frankenstein-style experiment has breathed life into the brains of pigs four hours after death.

Scientists in the US restored circulation and cellular activity in 32 pig brains obtained from a meat-packing plant.

While there was no evidence of re-awakening awareness or consciousness, the brains were said to be "cellularly active".

The study has huge implications that challenge long-held assumptions about the finality of death, and opens up a new frontier in brain research.

Lead scientist Professor Nenad Sestan, from Yale University, said: "The intact brain of a large mammal retains a previously under-appreciated capacity for restoration of circulation and certain molecular and cellular activities multiple hours after circulatory arrest."

Cellular brain death is usually considered to be swift and irreversible. Once the supply of oxygen and blood are cut off, the brain's electrical activity and signs of awareness vanish within seconds.

A cascade of destruction occurs leading to widespread degeneration from which there is no turning back.

However, Prof Sestan and his team noticed that small brain tissue samples routinely showed signs of cellular life returning, even when harvested hours after death.

To investigate further, they turned their attention to whole, intact brains from pigs processed for food production.

In a groundbreaking experiment, a specially designed "chemical blood" preservative was circulated through the brains of pigs that had been slaughtered four hours earlier.

The solution, warmed to normal body temperature, was perfused through the brains' blood vessels for six hours.

During this time the scientists observed a reduction in cell death and the restored functionality of certain nerve, blood vessel and glial cells.

Glial cells are important brain "support cells" that hold neurons in place, feed them with nutrients and oxygen, provide insulation, and clean up the carcasses of dead cells.

The revived activity even included some synaptic function, the transmission of signals between neurons.

Co-author Dr Zvonimir Vrselja said: "At no point did we observe the kind of organised electrical activity associated with perception, awareness, or consciousness.

"Clinically defined, this is not a living brain, but it is a cellularly active brain."

Lessons learned from the study could help doctors find ways to salvage brain function in stroke patients, or test the effectiveness of treatments to aid cellular recovery after injury, say the scientists.

Irish Independent

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