Household names losing out include former Justice Minister Alan Shatter for Fine Gael and Labour's Alex White, who lost his seat after the fourth count in Dublin Rathdown.
Gone too is Labour's Joanna Tuffy in Dublin Mid West and Eric Byrne, who conceded he had lost his Dublin South-Central seat around midday.
Fine Gael suffered another loss in Sligo-Leitrim with outgoing TD John Perry, while the party's deputy leader James Reilly is in a battle to keep his seat in Dublin Fingal.
Early indications seem to be coming true as Fianna Fáil, Sinn Féin, Independents and smaller parties look to make major gains at the expense of the Government.
So far, 27 seats have been filled, with Fianna Fáil on 12 , Fine Gael at 4, Sinn Féin also on 4, and Independents and Social Democrats both on 3.
Labour is still without a seat.
The new TDs who will be taking their seats in the 32rd Dáil come March, include Independent Alliance leader Shane Ross, who became the first TD elected this afternoon.
The Fianna Fáil leader Micheál Martin was the first party leader to be elected.
His party's Finance spokesman Michael McGrath was also returned in Cork South Central.
The first Fianna Fáil TD to win a seat was Seán Fleming with 13,626 votes in Laois.
Former party TDs Darragh O'Brien and Thomas Byrne, who have been bidding their time in the Senead, will return to the Dáil in March.
In Dublin Mid-West, Frances Fitzgerald for Fine Gael and Sinn Féin's Eoin Ó Broin took the first two seats for either party.
Outgoing Ceann Comhairle Seán Barrett was also automatically returned.
All three leaders of the Social Democrats - Stephen Donnelly, Catherine Murphy and Roisin Shortall have been elected.