Lee Evans says his comedy career is "finished" and he wants to retire to spend more time with his family.
The actor and comedian told Jonathan Ross he would quit comedy at the end of his current tour, saying: "This is it. Finished...it's the end."
Evans, who first found fame with his energetic, slapstick stage shows, has appeared in the theatre and films including There's Something About Mary.
He told Ross the death of his manager, Addison Cresswell, had "put things in perspective".
He said: "I don't know, I've come to a junction in my life where - please forgive me it sounds very narcissistic - I've done musicals and plays and films and stand up and you sort of get to a point where you go 'I don't know what else to do next'."
He added: "I want to go and see my wife, she deserves my time, I've been working solidly."