Mark Radcliffe and Stuart Maconie's popular evening show is being dropped from Radio 2 after four years.
The duo are to switch to digital station BBC 6 Music in a schedule shake-up for both services, although Mark will launch a new weekly one-hour show for R2.
And former daytime DJ Jo Whiley is to leave Radio 1 after 17 years to take a three-nights-a-week programme for 2 in the April overhaul.
Mark has been a major player on Radio 2 since 2004 following a switch from the more youth-oriented Radio 1, where at one stage he hosted the Breakfast Show with sidekick Marc Riley.
He has been broadcasting his evening show with old pal Stuart since 2007.
The pair will switch to 6 Music to front a daily three-hour 1pm show, replacing Nemone, who will move to a weekend slot.
Stuart will continue to present his Freakzone show for 6 Music and will also launch a mammoth 50-part history of pop series for Radio 2 next year.
The BBC said Mark and Stuart's new show will become an "integral part of 6 Music's daytime schedule and will reflect the rich relationship that the station has with Manchester and music from the North".
Jo had hosted a long-running weekday show for Radio 1 until last year. Since then she has been hosting a weekend show for the station but this will end with her Radio 2 move.
She will host a 90-minute show from Monday to Wednesday for R2 from April 4, when the new schedule is put in place.