Catherine Zeta-Jones is set to reunite with her Traffic director Steven Soderbergh in a new movie.
The Rebound actress is in the frame for a starring role in upcoming psychological thriller Side Effects, reports Deadline.
Jude Law, Blake Lively and Channing Tatum are also in talks about parts in the film.
Catherine, 42 - who has two children with husband Michael Douglas - will play a doctor in the film, which follows a depressed young woman who starts using prescription drugs to help her cope with her husband's forthcoming release from prison.
Jude and Channing have also worked with the award-winning filmmaker before. Sherlock Holmes star Jude starred in Soderbergh's Contagion, while Channing worked with the director on Haywire and Magic Mike.
Production is due to start in April in New York.