Bryan Singer is to direct X-Men: Apocalypse.
The filmmaker - who returned to the franchise with X-Men: Days Of Future Past, the second instalment of the new trilogy - has been in talks, but is now said to have "closed" his deal with Fox to take the reins on the upcoming film, reported Deadline.
It would be the 49-year-old's fourth stint as director on an X-Men film.
The next instalment, which is being written by Bryan, Simon Kinberg, Michael Doughterty and Dan Harris, is set to begin shooting in 2015, in time for a May 2016 release.
James McAvoy (Charles Xavier/Professor X), Jennifer Lawrence (Raven/Mystique) and Michael Fassbender (Erik Lensherr/Magneto) are expected to reprise their roles in X-Men: Apocalypse, which takes place a decade after the events of Days Of Future Past.
Along with Hugh Jackman's Wolverine and Nicholas Hoult's Hank McCoy/Beast, they have to join forces with the young Cyclops, Storm, Jean Grey and the other X-Men, possibly including Channing Tatum as Gambit, to fight their most formidable foe yet - an ancient unrelenting force determined to cause an apocalypse.
Director Bryan previously hinted that he is working on X-Men: Apocalypse for 2016, when he tweeted: "#Xmen #Apocalypse 2016!" He later shared a photo of the writing team on Twitter.
James has said his version of Charles will move towards Sir Patrick Stewart's portrayal.
"They would need to tie up his position because I've had lots of fun playing against people's expectations of Charles but ultimately you have to respect what he ends up being," he explained. "So in the third movie, he's got to start being like Patrick's performance."