Ice Cube is in talks to join Jonah Hill and Channing Tatum in 21 Jump Street, according to reports.
If the deal goes ahead, the US rapper-turned-actor will play a precinct captain in the film, Deadline said.
The movie, about undercover police officers who infiltrate high schools, will be directed by Phil Lord and Chris Miller.
Johnny Depp starred in the original 21 Jump Street TV series in the 1980s.
Asked recently about making a cameo appearance in the movie, Johnny told Extra host Mario Lopez: "I would do it in a second. I would be happy to do it. I'm sure there's some kind of fun to be had. Just waiting to be asked!"
The Sony Pictures film begins shooting in late April.