Asian shares and Wall Street futures fell on Monday as growing fears of a second wave of coronavirus infections revived economic worries, while underwhelming data from China also weighed on investor sentiment.
Monday's losses follow a strong global rally since late March, fuelled by central bank and fiscal stimulus and optimism as countries gradually lifted restrictions put in place to curb the spread of the novel coronavirus.
However, concerns are now swirling about a second wave with Beijing on Monday reporting its second consecutive day of record numbers of Covid-19 cases, while new cases and hospitalisations in record numbers swept through more US states.
The risk-off sentiment is also likely to weigh on global markets, with e-Minis for the S&P 500 extending losses in Asia to be down 2.7pc at 06:33 GMT, from 1pc earlier.
European markets were also set to open lower with pan-region EuroSTOXX 50 futures and German DAX futures each dropping 2.5pc and FTSE futures falling 2pc.
"Any new outbreak will be looked at very, very cautiously by investors. The market is putting into perspective that the Covid-19 issue has not been resolved yet. It's a reality check," said James McGlew, analyst at stockbroker Argonaut.
McGlew expects a further correction "as markets quantify what lies ahead of us."
Worldwide coronavirus cases have crossed 7.86 million with 430,501 deaths, according to a Reuters tally.
MSCI's broadest index of Asia-Pacific shares outside Japan was down 2.3pc, extending its losses from 0.3pc earlier in the day, with Australian shares off 2.2pc and South Korea falling 4.8pc.
Japan's Nikkei also extended losses to 3.5pc. Chinese shares joined the sell-off with the blue-chip CSI300 index down nearly 1pc.
"A more balanced assessment of economic risks and the probable recovery profile is materialising, at least in the short term. That makes it difficult to see the previous dynamism of upward momentum in risk appetite returning immediately," ANZ Research said in a report.
Economic data from China did little to revive risk appetite.
China's industrial output rose 4.4pc in May from a year ago, less than expected, while retail sales fell a larger-than-expected 2.8pc in a sign of weak domestic demand.
The Chinese yuan extended losses in offshore trade after the data to be last at 7.0883 per dollar.
Some analysts were still hopeful of a revival in sentiment.
"We assume that any second wave is likely to be more manageable than the first given earlier policy experience," analysts at Morgan Stanley wrote in a note.
"Policy easing will also help Asia (excluding Japan) get back on its feet better."
The risk-sensitive currencies of Australia hit $0.6779, the lowest level since June 2, after breaking below Friday's low of $0.6800.
Elsewhere, the safe haven Japanese yen rose on the greenback to 107.17 yen.
Analysts said further tests awaited global markets this week – in particular whether re-opening hopes could still push equities higher.
Federal Reserve Chairman Jerome Powell is also due to testify before Congress where "he may try to spin a more upbeat/hopeful outlook – but whether markets listen remains to be seen," said Betashares chief economist David Bassanese.
Oil fell more than 3pc on Monday, extending losses from last week, on worries renewed outbreaks of the coronavirus could weigh on the recovery of fuel demand.
Brent crude futures fell 3.5pc, to $37.39 a barrel by 06:12 GMT, while US West Texas Intermediate crude futures were down 4.9pc, to $34.49 a barrel.
Oil investors await OPEC+ committee meetings of experts later this week who will advise the producer group and its allies on output cuts.