A Louis Vuitton store in Sloane Street was ram-raided in the early hours of the morning by a gang who escaped on mopeds.
The Metropolitan Police were alerted at 12.50am on Tuesday to a burglary in progress at the up-market retailer.
Officers attended the incident and discovered a silver Ford Transit van had been driven into the shop and left at the scene.
The value of the items stolen is not known and no arrests have been made.
Anyone with information is asked to contact detectives at Kensington and Chelsea on 101 or to contact police on Twitter via @MetCC.