Barclays expects to axe up to 12,000 jobs this year to cut costs and counter falling income at its investment bank, where profits slumped last year.
But it is also paying staff higher bonuses, risking a backlash from the politicians and taxpayers who bailed out much of the industry during the financial crisis.
The bank said on Tuesday that 7,000 of the jobs will go in Britain and half of the affected staff there had already been notified. The latest cuts are not concentrated in any single business area.
Chief Executive Anthony Jenkins, who took the helm in 2012 after an interest rate rigging scandal, is pulling Barclays out of some investment banking activities as part of efforts to clean up standards and improve returns. The bank last year targeted 1.7 billion in annual cost savings.
It said it paid £2.4bn in incentive awards last year after raising bonuses in its investment bank by 13pc despite the profit decline.
That helped to lift Barclays' compensation-to-income ratio to 43.2pc last year from 40pc in 2012. It said it was still aiming for a compensation ratio in the "mid-30s".
Jenkins defended the increases, saying Barclays had to compete with global rivals to recruit the best staff. He said the bank was having constructive talks with investors over pay.
"We need to recruit people from Singapore to San Francisco. We need the best people in the bank to drive long-term sustainable returns for our shareholders," Jenkins told reporters on a conference call.
Shares in Barclays were down 1.9pc in early trade.
The bank had already released headline results showing its earnings dropped to £5.2bn last year, down 32pc from 2012, falling short of analyst forecasts as investment bank revenue slumped in the fourth quarter.
Profits at the investment bank slumped 37pc to £2.5bn, as income fell 9pc on the year to £10.7bn pounds due largely to a decrease in fixed income.
Barclays said it expects to improve its leverage ratio to at least 3.5pc by the end of next year as it reduces its balance sheet.
Its leverage ratio improved to just under 3pc by the end of the year from 2.2pc at the end of June. The UK regulator forced Barclays to raise £6bn from investors in October to improve its leverage ratio.
The bank said it remained committed to paying out 40-50pc of its adjusted earnings in dividends.
Barclays said it had cut its balance sheet by £196bn in the second half of last year, significantly more than the £65-80bn reduction it had targeted, helped by foreign exchange movements.
It said it would aim to cut at least another £63bn to get the balance sheet below £1.3 trillion, based on the UK regulator's calculation of leverage exposure.