Call of Duty: Modern Warfare 2 has become one of only a few entertainment franchises to take more than $1bn (€689m) in revenue.
The video game, which went on sale in November last year, made an estimated $550m in its first five days. It has now sold around 15 million copies, making it one of the best-selling video games of all time.
It has surpassed the 14.4 million units of Call of Duty: Modern Warfare sold in 2007, previously the bestselling title in the hugely popular six-year-old Call of Duty military shooter series.
It also joins the ranks of other $1bn titles such as Guitar Hero III and World of Warcraft, also owned by publisher Activision.
The figure also puts it alongside other entertainment franchises such as Avatar, the recent 3D science fiction blockbuster, which has become only the fifth film ever to gross more than $1bn worldwide.
Ahead of it are Titanic ($1.8bn), The Lord of the Rings: The Return of the King ($1.12bn) and Pirates of the Caribbean: Dead Man's Chest ($1.07bn).
Call of Duty: Modern Warfare 2 is also the best-selling videogame of 2009 in the UK, according to industry body Elspa.
"The phenomenal success of Call of Duty: Modern Warfare 2 was undoubtedly one of the leading entertainment stories of the year and firmly established videogames as one of the leading forms of entertainment in the UK," said Michael Rawlinson, Director General, Entertainment and Leisure Software Publishers Association.