Saturday 24 March 2018

Dr John Climax co-founded the Sandyford-based Icon Pharmaceuticals, which went on to become one of the world's biggest clinical trial companies, floating it on Nasdaq in 1998. The company is now valued at over $4.7bn.

Born in Singapore and now based in Foxrock, the entrepreneur sold 70m worth of shares when he stepped down as CEO in 2009 but still has a 2.2pc stake worth over $103m (97m) with shares performing strongly last year. His new company DS Bioharma, which is based in Leopardstown, last year spun out Afimmune to focus on pulmonary disorders and fibrotic conditions.

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