The Global Irish Economic forum will kick off in November with a series of regional meetings in Derry, Galway, Limerick and Laois.
The Department of Foreign Affairs-led forum will focus on issues including fostering entrepreneurship, targeting sectors with strong job-creation potential and boosting Irish exports in a diverse range of markets.
Invites have been sent out to participants from 40 countries around the world.
Attendees at previous forums include former US President Bill Clinton and Bob Geldoff.
Foreign Affairs Minister Charlie Flanagan said this year's forum is different from those in previous years.
"This is the first since Ireland successfully exited its bailout programme and our focus is firmly on sustaining and strengthening our robust economic growth," he said.