Julie Sinnamon, who has led Enterprise Ireland throughout the post-crash years, is stepping down.
The business development agency said yesterday that Ms Sinnamon would leave the post "later this year" and the recruitment process for a new CEO would begin soon.
"It has been, and remains, an honour to lead this organisation and to work with colleagues throughout Ireland and globally to support the success of Irish exporters," said Ms Sinnamon, who has been CEO since November 2013.
She said it had been her "absolute privilege and joy to work with ambitious companies throughout Ireland to help them realise their potential on the global stage. I will work with the organisation until later in the year to ensure an orderly transition."
Ms Sinnamon said that pending her departure she would continue to work with colleagues on finishing Enterprise Ireland's upcoming 2021-2025 corporate strategy.