US president Barack Obama will meet the Prime Minister on Monday ahead of the G8 summit in Northern Ireland.
He will also hold bilateral talks with Russian President Vladimir Putin on Monday evening.
The Syrian conflict has been high on the agenda of world leaders and David Cameron has said there is credible evidence of "multiple attacks" using chemical weapons by Syrian President Bashar Assad's regime.
The White House said: "The summit and related meetings will provide the President and his fellow world leaders an opportunity to address pressing economic, political, and security challenges around the globe and to promote the advancement of trade and greater transparency among G8 members and the developing world."
Mr Cameron has backed Washington's "candid assessment" that the Syrian regime has used chemical weapons.
President Obama has approved arming the Syrian rebels for the first time in response to the development, according to officials.
On Monday morning, the President and family will arrive in Belfast, where he will deliver remarks and engage with the people of Northern Ireland and highlight the "hard work, dialogue, and institutional development" they have undertaken together to advance peace and prosperity.
Michelle Obama will introduce the President at this event.