Wednesday 28 September 2016

Lardy Labradors have overeating gene - study

Published 04/05/2016 | 05:41

A study says an overeating gene can explain why some Labradors become obese
A study says an overeating gene can explain why some Labradors become obese

Labradors are often overweight because they have a gene linked to overeating, new research has suggested.

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The most common breed of dog in the UK and the US, Labradors are more likely to become obese than others.

Scientists at the University of Cambridge have discovered that 23% of the loveable dogs have a variant of an obesity-related gene strongly associated with weight and appetite.

In a study published today in the journal Cell Metabolism, a team of researchers studied 310 pet and assistance dog Labradors to look for variants of three candidate obesity-related genes.

They also examined the dogs' "food motivation" by asking owners about their animals' relationship with food.

The researchers found that a variant of one gene in particular, known as POMC, was strongly associated with weight, obesity and appetite in Labradors and flat coat retrievers.

In both breeds, for each copy of the gene carried, the dog was on average 1.9kg heavier, an effect size particularly notable given the extent to which owners, rather than the dogs themselves, control the amount of food and exercise their dogs receive.

Lead author Dr Eleanor Raffan said: "This is a common genetic variant in Labradors and has a significant effect on those dogs that carry it, so it is likely that this helps explain why Labradors are more prone to being overweight in comparison to other breeds.

The gene affected is known to be important in regulating how the brain recognises hunger and the feeling of being full after a meal.

"People who live with Labradors often say they are obsessed by food, and that would fit with what we know about this genetic change," says Dr Raffan.

The scientists even believe that understanding how the gene - which is also found in humans - works in dogs might help tackle the obesity crisis.

Professor Stephen O'Rahilly, Co-Director of the Wellcome Trust-Medical Research Council Institute of Metabolic Science, says: "Common genetic variants affecting the POMC gene are associated with human body weight and there are even some rare obese people who lack a very similar part of the POMC gene to the one that is missing in the dogs.

"So further research in these obese Labradors may not only help the wellbeing of companion animals but also have important lessons for human health."

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