Sunday 4 December 2016

Cats' black-and-white patches determined 'before the cradle'

Published 06/01/2016 | 10:06

The bicoloured patterning of piebald cats such as Sybil, the Downing Street cat, are determined in the womb, a new study has found
The bicoloured patterning of piebald cats such as Sybil, the Downing Street cat, are determined in the womb, a new study has found

Cats with black and white patches have their distinctive colouring determined in the womb, research suggests.

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The study found the two-tone fur colour, known as piebald, forms when pigment cells fail to follow instructions during early development.

Scientists hope the research will enhance understanding of medical conditions such as holes in the heart, which are also caused by problems with cell movements in the womb.

Piebald patches, also apparent in some horses, occurs when pigment cells move and multiply randomly as an embryo grows, without complex cell-to-cell communication sending them in one direction.

As there are not enough pigment cells to cover the whole of the skin, the animal gets a white belly, the study said.

The University of Edinburgh's Dr Richard Mort said: ''We already know cells move through the developing skin to create pigment. We have discovered that they move and multiply at random which is not what was expected.

"Using a mathematical model we were then able to show that this simple process could explain piebald patterns.''

This mathematical model could now be used for further research tracking different cells during early development.

Researchers at the Universities of Bath and Edinburgh carried out the research on mice and believe it debunks earlier theories that the odd colouring is the result of slow-moving pigment cells.

The University of Bath's Dr Christian Yates said: "Piebald patterns can be caused by a faulty version of a gene called kit. What we have found is counter-intuitive.

"Previously it was thought that the defective kit gene slowed cells down, but instead we've shown that it actually reduces the rate at which they multiply.

"There are too few pigment cells to populate the whole of the skin and so the animal gets a white belly.

"In addition to kit, there are many other genes that can create piebald patterns, the mathematical model can explain piebald patterns regardless of the genes involved.''

The findings were published in the journal Nature Communications.

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