The Canadian heartthrob played college student Ben Covington on the US TV show, with Keri as the curly-haired title character.
Last Resort star Scott told Playboy: "I've thought about a Felicity sequel. People want a reunion. I joke that I'd totally do it if it's years later and my character, Ben, weighs 500 pounds. He's a shut-in, and they're bringing paramedics and pulleys to get him out of bed."
He added: "That show didn't get massive ratings, but the fans we had were rabid. It makes you wonder what guys like Johnny Depp and Robert Pattinson go through. I never got near their level, but I was close enough to get my feet wet, to sort of peek around the corner, see the hysteria and say, 'No, thank you.'"
Scott went on to star in films such as Underworld and Barney's Version when Felicity ended in 2002.
Meanwhile, Keri recently wrapped filming on the sci-fi thriller Dark Skies.