Who Wants To Be A Millionaire is to be axed after Chris Tarrant said he wanted to step down as host, announcing: "It's time to take a break."
The 67-year-old said he had reached a point where he wanted to call it a day after being with the show since its inception and ITV has said there will be no further specials beyond the ones which have already been planned.
The groundbreaking programme was the first to offer viewers a chance to win a million pound prize, even if it was rarely ever reached, and became a major hit around the world. It also inspired the blockbuster movie Slumdog Millionaire.
Announcing his departure in a statement, Chris said: "It's been a huge part of my life for 15 years and I've loved every minute of it, but it is time for me to move on from Who Wants to Be A Millionaire.
"It's been the most remarkable journey and I consider myself very fortunate to have been associated with Millionaire from its inception. ITV have been fantastic in their support from day one and to see its huge success has been thrilling."
The show was a major part of ITV's schedule when it launched in 1998, appearing daily and Chris proved be a master of building tension. In recent years, it has been used more as a platform for fundraising celebrity specials.
Chris went on: " The calibre of the celebrities like Sir Paul McCartney, George Michael, Sir Alex Ferguson, Simon Cowell, Sir Tim Rice, Sir Terry Wogan, Jonathan Ross, Davina McCall, Stephen Fry, Matt Lucas, etc, is just one indication of how much this show has touched a nerve with everybody.
"But of course so much more rewarding for all of us has been, not just the celebrities or even the million-pound winners, but all of the ordinary men and women whose lives have been changed - sometimes forever - by being on the show.
"Thank you all for sitting opposite me. I am privileged to have been a part of it, but do now feel that it is time for me to call it a day. I've worked ridiculously hard these last few years and to quote myself, 'it's time to take a break'."