Andrea Corr, Aand 'Love/Hate' star Robert Sheehan were among those who took to the stage.
A host of big names staged a special event to to tell the stories of 11 human rights defenders who face down injustice despite the risk to themselves.
A highlight was 'West Wing' star Sheen, telling the story of three human rights workers from around the world before reciting the famous anti-apartheid speech given by Robert F Kennedy at the University of Cape Town, South Africa, on June 6, 1966, two years before his assassination in 1968.
"Each time a man stands up for an ideal or acts to improve the lots of others, or strikes out against injustice, he sends forth a tiny ripple of hope," said Sheen, reciting the passages to a hushed Vicar Street crowd last night.
The proceeds from the concert, at which Paul Brady, Liam O Maonlai, and Finbar Furey performed, were donated to Front Line Defenders, the international human rights organisation founded in Dublin in 2001.
Huberman said that Sheen had recruited her to help the organisation when they met shooting Irish film 'Stella Days' in 2010.
"It feels good to be doing something for such brave people," she told the Irish Independent.
Actor Robert Sheehan, looking striking different from the gangster he plays in RTE drama 'Love/Hate', said the individuals highlighted by the Front Line Defenders "were the bravest of the brave and deserved support."
President Michael D Higgins, an old friend of Sheen, was a special guest at the event.