Griffith all smiles on red carpet
The actors - who have a 17-year-old daughter together - said in a statement earlier this month that they were ending their marriage after 18 years.
E! News reported that a smiling Melanie stepped out at the Taormina Film Festival in Italy in a leopard-print dress.
Her wedding ring had been moved from her left ring finger to her middle finger, while her heart-shaped tattoo dedicated to her partner on her right shoulder had changed, with his name apparently faded.
The pair announced the end of their marriage earlier this month.
"We have thoughtfully and consensually decided to finalise our almost twenty years marriage in a loving and friendly manner honouring and respecting each other, our family and friends and the beautiful time we have spent together," they said.
Melanie cited irreconcilable differences in the court filing in Los Angeles.
The actress has been married four times, including twice to actor Don Johnson. Antonio has one previous marriage.