Hughes' position at Loftus Road had been under increased scrutiny after last weekend's 3-1 home defeat to fellow strugglers
Southampton made it 12 league games without a victory at the start of the season.
The Welshman appeared to have been given time to turn around the club's fortunes following a meeting with chief executive Philip Beard earlier this week, but his tenure has now been brought to an end after less than a year in charge.
Queens Park Rangers Football Club has today (Friday) terminated the contract of manager
Mark Hughes with immediate effect," the club announced on their official Twitter feed.