Injury woes worsen for Martin O'Neill after Daryl Murphy is ruled out of Wales clash
Assistant manager Roy Keane has confirmed that striker Daryl Murphy is out of the Republic of Ireland's World Cup qualifier against Wales on Friday night.
Newcastle striker Murphy underwent a scan on Monday to determine the extent of the calf injury with which he reported and he has now left the Ireland camp.
Murphy had hoped to be ready in time for the crucial Group D clash and Keane admitted his absence, with central defenders Shane Duffy and Ciaran Clark and midfielders Wes Hoolahan and Harry Arter already sidelined and Robbie Brady suspended, had come as a blow.
He said: "A lot of times we've turned up and lads have been doubtful but have managed to come through, but yes, it's disappointing.
"There's not much we can do, we're not in control of it. We're disappointed for a number of lads, but we just get on with it.
"We've got a good group still left and it's par for the course, just get on with it. We've got some good players behind and we'll take it as it comes."
Seamus Coleman and Jonathan Hayes sat out training once again as a precaution as they nursed swollen ankles, while Shane Long continued his recovery after his exertions for Southampton on Sunday, but all three are expected to train on Wednesday.
However, Everton midfielder James McCarthy, who reported despite having sat out with a groin problem in recent weeks, remains a doubt.
Keane said: "James didn't train today and I would say [he is] very doubtful. I think he had another scan yesterday and I think he might have done a bit of running with [head of fitness] Dan [Horan] today, but if he wasn't to join in the group tomorrow then he's highly unlikely to be involved on Friday.
"It's just too close to the game and the type of injury he's got, which is recurring."