Reigning European champions Chelsea will face Sparta Prague in the last 32 of the Europa League.
Chelsea, who failed to make the knockout stages of the top-tier European competition, will start their bid to become only the fourth club after Juventus, Ajax and Bayern Munich to win all of the major European trophies as they bid to usurp defending champions Atletico Madrid.
Tottenham will take on Ligue 1 side Lyon, starting with a home tie on Feb 14. The draw means that Spurs goalkeeper Hugo Lloris wil face his former club for the first time since his £12.3 million signing in August.
Chelsea avoided a rematch with Atletico, who handed them a 4-1 drubbing in the Super Cup back in August, and as a seeded team will start their Europa League campaign in Prague.
Liverpool travel to Zenit for their opening round of 32 match to face the Russian side who has hit the headlines this week when their largest supporters group, Landscrona, caused widespread outrage.
They posted an open letter on their website that outlined their preferred criteria for future signings at Zenit to exclude sexual minorities and non-Europeans from the playing staff.
Tottenham will play what could be one of the most hotly contested ties of the round when they face Lyon, who are a tough opponent more used to Champions League football.
It would be a much-anticipated match an evoke memories of when Gareth Bale scored a hat-trick at the San Siro for Tottenham against Inter in a match that eventually saw the north London side lose 4-3 in October 2010.
Full Uefa Europa League last 32 & last 16 draw
BATE Borisov vs Fenerbahce
Inter Milan vs Cluj
Levante vs Olympiacos
Zenit St. Petersburg vs Liverpool
Dynamo Kiev vs Bordeaux
Newcastle vs Metalist Kharkiv
Stuttgart vs Genk
Atletico Madrid vs Rubin Kazan
Ajax vs Steaua Bucharest
Basel vs Dnipropetrovsk
Anzhi Makhachkala vs Hannover
Sparta Prague vs Chelsea
Borussia Moenchengladbach vs Lazio
Tottenham vs Lyon
Napoli vs Viktoria Plzen
Napoli/Plzen vs BATE/Fenerbahce
Bayer Leverkusen/Benfica vs Dynamo Kiev/Bordeaux
Anzhi Makhachkala/Hannover vs Newcastle/Metalist Kharkiv
Stuttgart/Genk vs Borussia Moenchengladbach/Lazio
Tottenham/Lyon vs Inter Milan/Cluj
Levante/Olympiacos vs Atletico Madrid/Rubin Kazan
Basle/Dnipropetrovsk vs Zenit St Petersburg/Liverpool
Ajax/Steaua Bucharest vs Sparta Prague/Chelsea
First legs to be played Feb 14, second legs to be played Feb 21.