"It's a good draw," Perez said after the last-16 pairings were revealed. "We have played them twice before and knocked them out both times."
Real defeated United in the Champions League quarter-finals in 2000 and 2003.
"Well, it's the tie of the round," Ferguson said. "It's a great opportunity for our fans to see Cristiano again and also for me to meet up with Jose again – I'll need to order some good wine!"
Real will host United at the Bernabeu on February 13, with the return leg at Old Trafford on March 5.
The other two British teams in the draw do not have easy ties either.
"We will face a good team in Germany," Arsenal's German defender Per Mertesacker said. "They are top of the league and went through to the knockout stage in a phenomenal way. They have strong individual players and have created a great team."
In the Europa League draw, Chelsea have secured one of the easier ties.
Making their first appearance in the competition, Rafael Benitez's team will face Sparta Prague.
Tottenham Hotspur, managed by 2011 Europa League winner Andre Villas-Boas, have drawn French league leaders Lyons, a "tremendous" tie said Villas-Boas, who added that it was like a Champions League dress rehearsal.
All of the Europa League first-leg ties will be held on February 14 with the return legs on February 21. (© Independent News Service)