Video: Lancaster sights set on All Blacks model
If they do come on, Lancaster will have capped 16 new players in nine Test matches as he attempts to build an England team for the generation.
Lancaster is determined to emulate New Zealand and end the need for England to constantly rebuild the team at the start of every new World Cup cycle.
But he also maintains that England's long-term gain does not have to mean short-term pain.
"Someone said the All Blacks don't go through that period of renewal, it is a gradual drip-feed of new players -- and that is where we should be from now on," Lancaster said.
Exeter's Sireli Naqelevuki and Leicester's Vereneki Goneva will form a dangerous centre partnership for Fiji, while Gloucester's Akapusi Qera starts at No 8 after receiving a late call-up into the squad, which is captained once again by the Scarlets prop Deacon Manu.