UNCAPPED Gloucester centre Billy Twelvetrees will make his England debut in Saturday's Calcutta Cup game against Scotland after being selected in place of the injured Manu Tuilagi.
Other than the two injury-enforced changes, Lancaster has retained the starting line-up that laid the foundations for England's record 38-21 victory over New Zealand two months ago.
That means Tom Youngs keeps the hooker's jersey ahead of the more experienced Dylan Hartley, who missed the autumn series through injury.
"We are happy to stick with the team that did so well against New Zealand, especially in light of the fact that they have all been in good form for their clubs since then," Lancaster said.
"There were some very tight calls, with some experienced players coming back into contention, and I am sure the bench will have a significant impact on the game."
Tuilagi is expected to be available for England's second Six Nations appointment, against Ireland in Dublin a week on Sunday.
Twelvetrees is not a like-for-like replacement but he has a more rounded game than Tuilagi, offering a kicking game and a presence as a second playmaker outside Farrell.
The 24-year-old is also a powerful ball-carrier and defender, prompting Gloucester's director of rugby Nigel Davies to enthuse that he is the complete package for an inside centre.
England team to play Scotland in the RBS 6 Nations at Twickenham on Saturday, February 2 (kick-off 4pm)
A Goode (Saracens); C Ashton (Saracens), B Barritt (Saracens), B Twelvetrees (Gloucester), M Brown ( Harlequins); O Farrell (Saracens), B Youngs (Leicester), J Marler (Harlequins), T Youngs (Leicester), D Cole (Leicester), J Launchbury (Wasps), G Parling (Leicester), T Wood ( Northampton), C Robshaw (Harlequins, capt), B Morgan (Gloucester).
Replacements: D Hartley (Northampton), D Wilson (Bath), M Vunipola (Saracens), C Lawes (Northampton), J Haskell (Wasps), D Care (Harlequins), T Flood (Leicester), D Strettle (Saracens).