Flanker Yannick Nyanga was dropped from the France squad to face Italy in their Six Nations opener in Rome on Sunday when head coach Philippe Saint-Andre trimmed his group to 23.
However, both came through training unscathed, and along with Thierry Dusautoir – another Toulouse man – and Perpignan's Damien Chouly are the four loose forwards remaining in the squad.
"It is heartbreaking to have to tell Yannick that he has to leave," Saint-Andre said of the 25-times capped Nyanga.
Saint-Andre had decided to keep 24 players from the initial 33-man squad because of uncertainties surrounding the fitness of No 8 Picamoles, who was suffering from a thigh injury.
"Everything is fine, I've resumed training normally, so no worries," Picamoles said.
France (squad v Italy) – Backs: M Machenaud, M Parra, F Michalak, F Trinh-Duc, M Bastareaud, B Fall, W Fofana, F Fritz, Y Huget, M Mermoz. Forwards: V Debaty, Y Forestier, B Kayser, D Szarzewski, L Ducalcon, N Mas, Y Maestri, P Pape (captain), R Taofifenua, D Chouly, T Dusautoir, F Ouedraogo, L Picamoles.