There are only three survivors from the last Rabo game against Cardiff Blues in early January.
Nine who started that night are either injured or involved with Ireland while three more - Mike Sherry, Dave Foley and Tommy O'Donnell - are named on the bench.
There's a first start of the season for Danny Barnes and Ivan Dineen while JJ Hanrahan, Johne Murphy and Ian Nagle all get their second start of the year.
CJ Stander returns to the starting line-up after breaking a bone in his hand in the game against Glasgow back on December 1. He's picked at blindside in a back row along with Sean Dougall and James Coughlan who will captain the side.
MUNSTER (v Edinburgh): Denis Hurley; Johne Murphy, Ivan Dineen, JJ Hanrahan, Danny Barnes; Ian Keatley, Duncan Williams; Marcus Horan, Damien Varley, BJ Botha, Ian Nagle, Billy Holland, CJ Stander, Sean Dougall, James Coughlan (capt).