Murray and Earls back for Munster in crunch Rabo semi-final clash with Glasgow Warriors
BJ Botha returns at tight-head to join Varley and Dave Kilcoyne in the front row.
Conor Murray returns to the starting line up to partner Ian Keatley in the half backs while Casey Laulala will earn his 50th cap for Munster when he lines out alongside James Downey in the centre.
The back three sees winger Keith Earls make his first start since Munster's Heineken Cup defeat to Toulon partnering Simon Zebo on the opposite wing while Felix Jones retains his place at fullback.
Andrew Conway returns to the match day squad after sustaining a sprained toe against Edinburgh.
Munster XV: Felix Jones, Keith Earls, Casey Laulala, James Downey, Simon Zebo; Ian Keatley, Conor Murray; Dave Kilcoyne, Damien Varley - Capt, BJ Botha; Dave Foley, Paul O'Connell; CJ Stander, Sean Dougall, James Coughlan. Replacements: Quentin MacDonald, James Cronin, John Ryan, Donncha O'Callaghan, Paddy Butler, Duncan Williams, JJ Hanrahan, Andrew Conway.