The bonus-point win ensured that Quins only have to secure one point from their remaining two games to top Pool 3 and hopefully secure a home draw in the quarter-finals. Quins took some time to subdue the visitors but once Zebre picked up two yellow cards in quick succession, it was a case of damage limitation as the home side scored seven tries and collected 18 points from the boot of Nick Evans.
Quins were ahead within three minutes with a simple penalty from Evans before the outhalf set up the first try with only seven minutes gone. Quins were frustrated for the next 20 minutes due to some stout defence from the visitors, who ended up collecting the next score.
Luciano Orquera missed with a long-range penalty but soon made amends, sailing through a huge gap to help set up Ruggero Trevisan's try. Evans then converted after a Quins penalty try to give the hosts a 20-5 interval lead. It was more of the same after the break as relentless Quins piled on the misery.
Scorers – Harlequins: Penalty try; T Casson, B Botica, N Easter, S Smith, D Care, K Dickson tries; N Evans 2 pens, 6 cons. Zebre: R Trevisan try
Harlequins: Brown (Dickson 62), Monye (Botica 41), Hopper, Casson, Smith, Evans, Care, Lambert (Marfo 41), Gray (Buchanan 59), Collier (Sinckler 59), Matthews (Twomey 59), Robson, Guest, Robshaw, Easter (Wallace 52)
Zebre: Trevisan, Venditti, Pace (Garcia 41), Halangahu (Cristiano 51) , Sarto, Orquera (Pratichetti 68), Chillon (Martinelli 51), De Marchi (Perugini 33), Giazzon (Manici 51), Redolfini (Fazzari 41), Van Vuren, Sole, Cattina (Belardo 61), Ferrarini, van Schalkwyk
Referee: M Raynal (France)