Gordon D'Arcy and Eoin Reddan back for Leinster ahead of Munster clash
Australian international Lote Tuqiri may also be line to make his debut for the Blues.
McLaughlin and Fergus McFadden - who successfully came through his first outing in the RDS this season - both now lie three appearances short of the 100-cap mark for their home province.
Cian Healy, Jamie Heaslip, Rob Kearney and Brian O'Driscoll all came through their first starts of the campaign, while Sean O'Brien is in the frame for the first time this season ahead of the trip to Limerick. Dominic Ryan's next appearance will be his 50th in Leinster colours.
O'Brien could be joined in the panel this week by Australian international Lote Tuqiri, while fellow winger Darren Hudson (hamstring strain) is responding well to treatment and could return to action over the next fortnight.