A second-half resurgence from Munster denied Zebre their first ever win in the RaboDirect Pro12 as the Irish province recorded a 43-21 victory.
Two JJ Hanrahan penalties gave Munster an early lead but Orquera halved the deficit and then crossed for the opening try after catching Munster off guard with a quick tap penalty.
Hanrahan brought his side back to within a point but hooker De Marchi surprisingly popped up on the end of a flowing move and outpaced Munster full-back Hurley to score.
Half-time substitute James Downey quickly won a penalty from which Hanrahan cut the deficit and it sparked a dramatic second-half comeback.
Butler's try and Hanrahan's conversion put Munster 19-18 up, before Stander's try extended their cushion.
Filippo Ferrarini wasted a three-on-one chance to bring Zebre back into the game and replacement fly-half Keatley converted his own try to round off Munster's win