Winner of the 2009 Irish Open as an amateur and then last season's Portugal Masters, Lowry will play in Tucson next week if Phil Mickelson confirms he is not going to be part of the 64-man field for the second year running.
The seeded draw is not made until the rankings are updated again next Sunday night, but as things stand Lowry would face world number one Rory McIlroy in the opening round.
Swede Fredrik Jacobson needed to come seventh on his own at Pebble Beach tonight if he was to push Lowry down to 66th in the world, but finished joint seventh when American Patrick Reed sank a birdie putt on the final green - and that after driving onto the rocks.
“Absolutely buzzing for the Matchplay next week,” the Offaly man tweeted this morning.
Meanwhile, American Brandt Snedeker is at a career-best fourth in the world after following up back-to-back runner-up finishes with victory at the Pebble Beach Pro-am.
Snedeker relegates Justin Rose and Louis Oosthuizen to fifth and sixth respectively on the new rankings, while Richard Sterne's seven-shot win at the Joburg Open moves him up from 94th to 55th and into the field for next week's Accenture Match Play Championship in Arizona.
Latest leading positions in the world golf rankings: 1 Rory McIlroy 12.03pts, 2 Tiger Woods 9.03, 3 Luke Donald 7.58, 4 Brandt Snedeker 6.91, 5 Justin Rose 6.44, 6 Louis Oosthuizen 6.44, 7 Adam Scott 5.85, 8 Lee Westwood 5.50, 9 Bubba Watson 5.28, 10 Phil Mickelson 5.16
Other: 19 Graeme McDowell, 48 Padraig Harrington, 65 Shane Lowry.