World statesmen, literary giants and Hollywood legends have performed the ritual and now TV's favourite yellow-bellied character Homer Simpson is set to kiss the famous Blarney Stone on Tuesday.
To mark St Patrick's Day, the world's most dysfunctional family travel to Co Cork for a special 'Oirish' episode of 'The Simpsons'.
Entitled 'In the Name of the Grandfather', it will receive its television premiere on Sky1 at 7.30pm on St Patrick's Day.
It will be the first time in the 20-year history of the show that an episode will be aired to audiences outside of US first.
Bookmakers are even offering odds on what will happen during the episode.
Paddy Power is taking bets on whether Homer will hold baby Maggie out to kiss the stone instead, whether he'll lick the stone, vandalise it with graffiti, or even worse, urinate on it.
"We're no strangers to betting on 'The Simpsons'," says spokeswoman Sharon McHugh. "We're still feeling the pain from the massive payout we faced when baby Maggie shot Mr Burns all those years ago," she said.
The betting firm is also speculating on what famous Irish cliche Homer will utter first, with "Oh begorrah", "top of the morning to you", and "to be sure, to be sure" the top three favourites.
Actor Colin Farrell is currently 3/1 to put in a celebrity appearance during the episode.