US internet shopping giant Nextag is already recruiting for some of the 125 positions it will create at its international headquarters.
It said the skills of the Irish workforce plus the corporation tax rate helped persuade the company to locate here.
Senior vice-president of finance and corporate development, Derek Yung, said the firm had already opened a data centre in Dublin and was now locating its international headquarters in Drogheda with support from the IDA.
He insisted that Ireland's economic difficulties were no reason for companies to avoid basing themselves here.
"In terms of where we establish our headquarters, that hasn't been something we have discussed," he said.
This was reiterated by the chief executive of IDA Ireland, Barry O'Leary, who said such companies "are not coming to Ireland to service the Irish market".
He added: "Nor are they coming to raise finance nor do they need to deal with the local banks.
"They are looking at the talent pool here -- whether we have a strong track record, do we have a good corporation tax and good technology capability. That is what is important to them."
The positions being filled initially are in administration and finance, and according to Mr Yung, the salaries will "vary significantly".
"We are hiring people with experience for senior positions and we are hiring entry-level as well."
Nextag is expected to base its offices at the old Ulster Bank building on South Quay in Drogheda.