Fine Gael has formally selected sitting MEPs Mairead McGuinness and Jim Higgins as the party's candidates in the Ireland Midlands-North-West.
The party is aiming to take two out of four seats in the constituency that sprawls across 15 counties of Connaught, Ulster and north Leinster.
Taoiseach Enda Kenny encouraged party activists to canvass on behalf of the two candidates.
Ms McGuinness said jobs would be the most important issue in the European elections.
She pointed to the EU funding allocated to providing training, apprenticeships and placements for young people, known as the European Youth Guarantee.
Ms McGuinness said it was important for voters to elect MEPs who would do the work and not just be protesting.
"Elect people who stay the course and will deliver for this constituency and this country," she said.
She said the public had lost trust in all institutions.
Mr Higgins said this year's local and European elections would be different from the two previous campaigns in 2004 and 2009, when the party was in opposition.
"At the end of the day, we are going to be judged and the votes are going to fall on the basis of the performance of the Government," he said.