Two Indian firms are to create 75 jobs in Dublin.
Aditi Technologies, a technology services company, is to open its European Services and Business Development Centre in Dublin with the creation of 40 local jobs.
And Synowledge - which specialises in the drug safety and regulatory affairs services for the pharmaceutical, biotechnology and medical device sectors - is establishing its international headquarters in the capital, creating 35 high-quality jobs.
Mr Bruton said Alti Technologies is a dynamic and innovative "cloud first" company operating in a high- growth area.
"For companies in the ICT sector and for the Irish economy the Cloud offers great opportunities," he said.
Both investments are supported by the Department of Jobs, Enterprise and Innovation, through IDA Ireland.
Kaushik Banerjee, vice president Europe, Aditi Technologies, said: "Ireland offers an encouraging investment climate with investor- and business-friendly policies so it became an obvious choice for us when looking at our expansion in Europe.
"There is also a wealth of local technology talent which we are looking forward making part of Aditi."
Elsewhere, Synowledge's new Dublin office will develop business for non-US markets.
The Irish operation will also carry out sales and marketing for the entire Synowledge product portfolio and will provide near shore delivery of the company's pharmacovigilance, regulatory and IT services to Europe.
Sankesh Abbhi, president and chief executive, said the firm was proud to be recognised recently as one of the fastest growing private companies in the US.
"Ireland was a logical choice for our International base to seamlessly connect with our US HQ and our delivery centres in Europe, India and Japan," he said.
"Being in the drug safety, IT and regulatory affairs fields, Ireland's profile as a hub for the global life science sector and its cosmopolitan talent pool were also key factors in our decision."
Barry O'Leary, of IDA Ireland, said Synowledge would become an important part of the pharmaceutical regulation and compliance industry in Ireland.
"In addition, Synowledge is predominately Indian-based and represent an important win for IDA Ireland as we develop our pipeline of Indian companies," he added.