Tuesday 27 September 2016

Signs of Alzheimer's can be seen from age of three

Sarah Knapton

Published 14/07/2016 | 02:30

An inherited gene linked to Alzheimer's disease can affect the brains and thinking ability of young children in the first years of life, research suggests Photo: Dominic Lipinski/PA Wire
An inherited gene linked to Alzheimer's disease can affect the brains and thinking ability of young children in the first years of life, research suggests Photo: Dominic Lipinski/PA Wire

The Alzheimer's gene, which seriously raises the risk of developing dementia, is already affecting carriers by the age of three, shrinking their brains and lowering cognition, a study suggests.

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Children who carry the APOEe4 gene mutation, which raises the chance of dementia fifteen-fold, were found to do less well in memory, attention and function tests. Areas of the brain affected by Alzheimer's disease, such as the hippocampus and parietal gyri, were also found to be up to 22pc smaller in volume.

Around 14pc of people carry the APOEe4 mutation. The research is the first to show that genetic changes which can lead to Alzheimer's are affecting the brain very early in life.

Scientists from the University of Hawaii, Yale and Harvard say screening for the gene could help doctors identify which children could benefit from early interventions, such as educational help, preventative treatments, health monitoring and increased exercise.

The study involved 1,187 people aged between three and 20 who took part in genetic tests and brain scans, as well as undertaking a series of tests to measure their thinking and memory skills.

Lead author Dr Linda Chang said: "The APOEe4 carriers show the strongest effects, with negative influences on brain structures and cognition mirroring those in elderly participants and patients with Alzheimer's disease."

The most common kind of dementia is Alzheimer's disease. But scientists are still struggling to determine what causes the condition, and despite 412 drug trials, nothing has been shown to combat the disease so far. The researchers think the APOEe4 gene slows brain development and could be a target for future medication. APOEe4 is also known to make people susceptible to disease, so some scientists believe Alzheimer's could be triggered by an infection and may be fought with antibiotics.

Ian Le Guillou, research officer at Alzheimer's Society in the UK, said: "These interesting findings suggest that people with the APOEe4 gene have differences in their brains from childhood."

He added: "Although people with the gene are at an increased risk of dementia, there are still things they can do to lower their chances of developing the condition. This includes taking regular exercise, not smoking and keeping their blood pressure in check."

The research was published in the journal Neurology.

Irish Independent

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