Saturday 1 October 2016

Pill will help doctors to find cancer tumours with light

Ella Pickover in London

Published 16/03/2016 | 02:30

The oral tablet contains an imaging agent that selectively binds to cancer cells or blood vessels that are unique to tumours, scientists said.
The oral tablet contains an imaging agent that selectively binds to cancer cells or blood vessels that are unique to tumours, scientists said.

Scientists have created a "breast cancer diagnosis pill" that it is hoped will save thousands of lives.

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Researchers have developed a tablet that lights up cancerous tumours in a mouse's breast tissue under near-infrared light.

Current screening methods often identify lumps, but cannot always pinpoint which ones are cancerous.

In a bid to resolve this uncertainty, researchers from the University of Michigan in the US created a pill that only highlights cancerous tumours.

The oral tablet contains an imaging agent that selectively binds to cancer cells or blood vessels that are unique to tumours, scientists said.

Once the agent has bound to the cancerous cells, the dye fluoresces under near-infrared light, the researchers discovered.

Mice

When testing the imaging technique in mice, the research team found that fluorescent tumours can be detected 1cm to 2cm deep.

They found that the imaging agent binds specifically to cancer cells with "little background noise" in the image.

The team now plan to formulate the pill for humans. If successful, the new technique could benefit women with 'dense' breast tissue, whose mammograms are typically more difficult to read, they said.

The findings are to be presented to the National Meeting and Exposition of the American Chemical Society.

"There's a lot of controversy right now about when patients should start screening for breast cancer," research lead, Dr Greg Thurber, said.

"Screening can potentially catch the disease early in some patients, but false positives can lead to unnecessary, aggressive treatments in patients who don't need them.

"We don't know how to select the right patients to treat. Our work could help to change that."

Irish Independent

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