Friday 22 September 2017

Human versions of 'supermouse' may cure deadly cancer

Supermouse is cancer-immune
Supermouse is cancer-immune

John von Radowitz

Human versions of a cancer-immune "supermouse" are spearheading a multi-million pound research project aimed at finding a cure for one of the deadliest forms of the disease.

Scientists are to search for special individuals whose innate immune systems provide a powerful defence against cancer.

Their cancer resistance mirrors that of a mutant lab mouse that astonished researchers with its ability to shrug off aggressive cancers.

The bold plan is to use white blood cells from these people - who make up a small fraction of the population - to develop a potential cure for pancreatic cancer in the next four years.

The disease has one of the highest cancer fatality rates, with only 3.3pc of patients surviving five years after diagnosis.

With adequate funding the team hopes to launch a clinical trial as early as next year.

"This could be game-changing," Alex Blyth, chief executive of LIfT BioSciences, the British biotech company pioneering the treatment in partnership with King's College London, said.

"It's a cell therapy, taking cells from people who have a high-functioning innate immune system and transferring them to people with a lower level of cancer-killing activity.

"On average, cancer patients have much lower activity in their granulocytes, a family of white blood cells that has consistently been overlooked. It wasn't even recognised that they killed cancer cells until recently."

Mr Blyth, whose mother died from pancreatic cancer in 2014, added: "Currently 97pc of patients with pancreatic cancer today will be dead in five years, and that hasn't really changed in 40 years."

Early research indicates the same approach could work for other solid cancers, such as those affecting the prostate, breast and bladder.

The project developed from the discovery in 1999 of a mutant mouse with an almost miraculous ability to ward off aggressive cancers.

Scientists at Wake Forest University in the US found the "supermouse" passed on its cancer-beating powers to 40pc of its offspring. When white blood cells from these mice were injected to normal mice, they too became cancer-resistant.

Irish Independent

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