DR Muhammad Taufiq Sattar said he had no animosity towards Ryanair for charging him €188 to change his flight so he could rush to England after his family perished in a fire.
The surgeon was asked to stump up the fee to catch an earlier flight, despite telling airline staff about the tragedy.
Ryanair said yesterday it had refunded the charge.
Dr Sattar said he had "no issue" with the airline and wanted to "forget about it", adding that he was due to fly with them again.
Asked by the Irish Independent about forcing Dr Sattar to pay to change his flights, Mr O'Leary denied it was outrageous.
"It wasn't outrageous. The staff were implementing our policy. But I think you have to make exceptions in cases like that and we clearly made an exception once we became aware of it last night," he said.
"We immediately refunded to Dr Sattar the money that we regret having taken from him in such tragic circumstances."