Winona Ryder has reportedly refused to appear on-screen with Johnny Depp again, as she believes his romance with Amber Heard is "inappropriate".
The 42-year-old actress and heartthrob actor were set to tie the knot while they dated from 1989 to 1993 and starred opposite each other in Edward Scissorhands.
However, the 50-year-old star and Vanessa split up in 2012 and he is thought to have been seeing his 27-year-old Rum Diary co-star Amber Heard behind her back, who he is now engaged to.
This controversial move allegedly angered Winona and a source told RadarOnline she "had a respectful relationship with Johnny for years afterward, but she soured on any idea of an acting reunion after Johnny hooked up with Amber."
"The way he conducted that affair really upset Winona and turned her off to Johnny. The thing she especially can't stand is how all of Johnny's middle-aged friends, even Tim Burton, are cheering this relationship on like it's appropriate, when Winona is telling her own friends that it's absolutely not," the source explained.
"She's pulled a 180 on her opinion of Johnny and his cronies because she thinks it's a sad cliché that he'd dump his long-term baby mama for a woman in her twenties."
Johnny and his new fiancée stepped out in public as a couple for the first time earlier this month at the Art of Elysium's 7th Annual Heaven Gala.
Despite having been single for a while now, the brunette beauty is said to be content with her set up.
"Winona generally has become much more conservative as she hits her forties, but still is making no indication of settling down," the source added.
"She loves living alone. That's her big thing and the reason most of her relationships fall apart after the first year."