The show was in the front-running for the award, which is voted for by British viewers, and follows a BAFTA win last year.
Sporting a bright pink bowtie and a polkadot waistcoat, the Dubliner took to the stage at the O2 in London alongside members of the cast.
A ratings juggernaut, the comedy's Christmas special pulled in over 1.8 million Irish viewers over two nights on RTE and over 17 million when it was screened on the BBC.
The 57-year-old Dubliner has announced that there won't be a fourth series of the sitcom next year as he concentrates on taking the characters to the big screen.
He recently filmed a pilot for a new TV game show for the BBC, 'Mrs Brown's Celebrities', and said the Dublin mammy had the British stars in stitches. If given the green light, it is being geared for a primetime Saturday night slot.
He said: "Basically it's Mrs Brown taking the mickey out of famous people because she doesn't know who they are.
"We shot a pilot episode with Kate Garraway, Robbie Savage and Russell Grant and they were crying with laughter.
He said in an interview in 'TV Times': "It might make Mrs Brown a bit more famous but we can't get any more people into the gigs than we already do.
"I was weighing it up and commercially it makes no sense but watch this space."
And despite being a hit in Ireland, the UK and further afield, he said he does sometimes worry that Mrs Brown is on screen too much.
'Mrs Brown's Boys' was up against 'Absolutely Fabulous', 'Benidorm' and 'The Big Bang Theory' for the best sitcom award.
Meanwhile, Armagh actor Colin Morgan (27) fought off competition from Benedict Cumberbatch in 'Sherlock' and 'Doctor Who's' Matt Smith to scoop the award for best male drama performance for his role in the BBC1 series 'Merlin'.
Also nominated for an award was Dublin actor Emmett Scanlan (32) who plays villain Brendan Brady in Channel 4's 'Hollyoaks'. He was shortlisted for best serial drama performance but lost out to Alan Halsall of 'Coronation Street'.